Crossref indexed

Toxicology and Applied Pharmacology

Published by Elsevier.

ISSN 0041-008X / 1096-0333

Aims & scope

Toxicology and Applied Pharmacology publishes peer-reviewed research. Manuscripts pass a technical check and a scope check by the handling editor before going to independent reviewers.

Recently published

Impact of chronic oral aflatoxin B1 exposure on iron metabolism in a pig model

Magdalena Ogłuszka, Katarzyna Kępka-Borkowska, Xiuying Wang, Wojciech Kozera, Adam Lepczyński, Marta Marynowska, Elżbieta Redlarska, Brygida Ślaska, Hiroaki Taniguchi, Paweł Lipiński, Katarzyna Chałaśkiewicz, Krzysztof Karpiesiuk, Piotr Suder, Małgorzata Hopciaś, Chandra Shekhar Pareek, Paweł Grychnik, Kaja Ziółkowska-Twarowska, Angelika Tkaczyk-Wlizło, Małgorzata Ożgo, Agnieszka Herosimczyk, Klaus Wimmers, Mariusz Pierzchała, Rafał Radosław Starzyński · 2026

DOI 10.1016/j.taap.2026.118044

Tubuloside A alleviates sepsis-associated kidney injury by modulating the mTOR-NF-κB pathway

Qingyan Ni, Mingxue Wang, Xiaoying Pu, Shujuan Liu, Xiaolong Xu, Mian Fu · 2026

DOI 10.1016/j.taap.2026.118067

NRF2 activation mediates the protective effects of capsaicin against MGO/STZ-induced chondrocyte apoptosis and diabetic articular cartilage injury

Yanshuai Wang, Mingbo Cao, Zhiyuan Liu, Zhendi Wang, Jingqi Fu, Huihui Wang, Yuanyuan Xu, Jinzhi Wu, Jingbo Pi · 2026

DOI 10.1016/j.taap.2026.118068

ATF3 inhibits retinal pigment epithelial cell injury by activating HSPA5:A mechanistic insight for diabetic retinopathy

Xiang Li, Hongpei Cui, Xiaoyang Shi, Manli Li, Chao Niu, Yongfeng Gao · 2026

DOI 10.1016/j.taap.2026.118077

Maternal cannabis use during pregnancy associates with alterations in placental endocannabinoid- and steroid-homeostasis and morphology

M.S. Harhangi, P. Meier, H.H. Bijma, L.E. van der Meeren, M. Rousian, A.G.M.G.J. Mulders, R.P.M. Steegers-Theunissen, S.H.P. Simons, I.K.M. Reiss, A.H.J. Danser, J. Gertsch, M. Broekhuizen · 2026

DOI 10.1016/j.taap.2026.118080

10-gingerol potentiates paclitaxel efficacy in triple-negative breast cancer by remodeling gut microbiota and suppressing PI3K/AKT/mTOR signaling pathway

Yaning Xu, Ruirui Zhao, Haopeng Chen, Xiaohan Li, Qian Zhang, Saixuan Zhang, Xinyu Bai, Hai Lu, Zhiyong Xie · 2026

DOI 10.1016/j.taap.2026.118071

Comparison of alveolar macrophages senescence between cigarette smoke-exposed and naturally aged mice and the role of P2X7R in CS-induced airway inflammation

Ping Huang, Xichen Pang, Zhe Wang, Xiaofeng Li, Tingting Zhang, Sha Huang, Lulu Zhang, Xinrui Qiao, Xiaoli Zeng, Xiaoju Liu · 2026

DOI 10.1016/j.taap.2026.118088

Development of an adverse outcome pathway (AOP): Stimulation of toll-like receptor (TLR) 7/8 induces psoriatic skin disease

Shogo Matsumura, Hiroyuki Komatsu, Shinko Hata, Takumi Ohishi, Junichiro Sugimoto, Ken Goto, Yasuharu Otsubo, Sumie Konishi, Kiyoshi Kushima, Yasuhiro Yoshida, Tomoki Fukuyama, Tadashi Kosaka, Shigeru Hisada, Takao Ashikaga · 2026

DOI 10.1016/j.taap.2026.118092

Levonorgestrel-ethinyl estradiol impairs hepatic lipid clearance to induce hypercholesterolemia via PCSK9-mediated LDLR and CD36 dysregulation

Bingzhi Li, Chenji Ye, Zhuo Wang, Junying Zhang, Zeyu Fan, Yinghui Huo, Xianwei Wang, Fenghua Lv · 2026

DOI 10.1016/j.taap.2026.118047

A longitudinal characterization of cardiopulmonary and systemic injury following acute chlorine inhalation in rats

Gajanan R. Jadhav, Amber J. Johns, Iram Zafar, Aftab Ahmad, Shama Ahmad · 2026

DOI 10.1016/j.taap.2026.118062

Tuberostemonine produces antidepressant effects via the BDNF/TrkB/Erk/CREB signaling pathway

Fan Chen, Liwei Li, Xiaoxia Xu, Ziyao Meng, Qin Yu, Linjie Chen, Qi Ai, Yu Deng, Jurui Wei, Guang Liang, Xia Zhao, Houming Yu · 2026

DOI 10.1016/j.taap.2026.118064

Development of an in vitro chemical hazard screening method using human iPSCs with and without metabolic activation and application to chlorinated paraffins

Islem Boukara, Mari Ochiai, Hisato Iwata · 2026