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Bioorganic Chemistry
Published by Elsevier.
ISSN 0045-2068 / 1090-2120
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Aims & scope
Bioorganic Chemistry publishes peer-reviewed research. Manuscripts pass a technical check and a scope check by the handling editor before going to independent reviewers.
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Recently published
Structurally diverse polyprenylated acylphloroglucinols from Hypericum addingtonii with anti-hepatocellular carcinoma activity
DOI 10.1016/j.bioorg.2026.110638 Jiandong Chen, Lan Yang, Suchen Li, Yan Hu, Weiming Sun, Dongmei Shi, Rongcai Yue, Peng Li, Changxi Yu, Weijia Lu · 2026
A synergistic platform integrating iodinated BODIPY photosensitizers and microglial cells for superior photodynamic antibacterial efficacy
DOI 10.1016/j.bioorg.2026.110663 Mingmin Gu, Jian Li, Bo Liu, Nan Yang, Maoran Lang, Yali Han, Bo Kou, Ping Yang, Wenzheng Ding, Wenhai Lin, Songqing Zhu, Qiang Tong, Li Quan · 2026
Non-chelating 2-(arylthio)acetophenone derivatives as broad-spectrum tyrosinase inhibitors: Synthesis, in silico profiling, in vitro, and in vivo antimelanogenic efficacy
DOI 10.1016/j.bioorg.2026.110562 Yeonsoo Jeong, Hyunju Lee, Hee Jin Jung, Hyejin Kang, Minchang Kim, Hyunhee Ju, Somin Hwang, Hae Young Chung, Hyung Ryong Moon · 2026
Design, synthesis, and cytotoxic activity evaluation of 1,2,4-Triazole-based Ethanone and Ferrocenylchalcone derivatives: A comparative study
DOI 10.1016/j.bioorg.2026.110567 Nuran Kahriman, Ali Aydın, Sıla Can Osmanoğulları, Fatma Demir, Olcay Bekircan · 2026
C-4-functionalized cyclogeraniols from saffron: Structural diversity, Enantiomerism, and stereochemistry-dependent anti-melanogenic activity
DOI 10.1016/j.bioorg.2026.110696 Ting-Ting Li, Si-Bo Ji, Si-Qi Ma, Han-Qi Zhang, Bai-Xiang Cai, Muaitaer Nuermaimaiti, Ju-Tao Wang, Guo-Kai Wang, Yang Yu · 2026
Bio-templated synthesis of crystalline nanocellulose/MgO hybrids from Withania somnifera: for selective anticancer, antioxidant, and anti-inflammatory activity.
DOI 10.1016/j.bioorg.2026.110593 H. Nagaraja, Monica K.J. Nidhi, A. Ganesh, H. Shivaraj, B. Uma Reddy · 2026
Non-fluorescent benzothiadiazole probe with protein-triggered turn-on fluorescence for imaging SARS-CoV-2 spike protein in biological systems
DOI 10.1016/j.bioorg.2026.110557 Brenno A.D. Neto, Alberto A.R. Mota, Hannah P. Mota-Araujo, Lilian C. Colodeti, Isalira Peroba Ramos, Erick F. Santos-Rodrigues, Ketley Oliveira-Santos, Jose R. Correa, Ana Beatriz Walter-Nuno, Luana L. Reis, Daniel F. Scalabrini-Machado, Lúcio R. Vieira, Claudia P. Figueiredo · 2026
Pinnatifolin from Syringa pinnatifolia protects against myocardial ischemic injury in mice by targeting GPX4 to suppress ferroptosis
DOI 10.1016/j.bioorg.2026.110620 Yize Xiao, Qiuyuan Ding, Jingjing Sun, Kun Gao, Xiaomin Liang, Guodong Yang, Jessore Jurat, Xiaoli Gao, Xingyun Chai · 2026
Discovery and optimization of N-phenylbenzenesulfonamide analogues as novel ALKBH5 inhibitors for AML therapy
DOI 10.1016/j.bioorg.2026.110658 Qiuting Xu, Shuying Xie, Jiachen Wei, Qinkuai Wu, Meng Xiao, Yike Ma, Hailang Xu, Wenxiu Wang, Xicheng Chen, Xiaoke Gu, Mingshan Niu, Jingying Qiu · 2026
Indole-based peptidomimetic maleimides as SARS-CoV-2 Mpro inhibitor scaffolds compatible with reversible covalent inhibition: Warhead optimization and broad in vitro antiviral activity
DOI 10.1016/j.bioorg.2026.110561 Pengyao Jin, Yangjie Zeng, Zhida Fan, Mengguang Liu, Likang Zhai, Rugui Xiao, Yali Zhang, Xiaodong Ren · 2026
Magnolol protects against cisplatin-induced ototoxicity by reducing oxidative stress through PPAR-γ
DOI 10.1016/j.bioorg.2026.110702 Ziyi Tang, Rui Luo, Chunyan Wang, Jian Zhou, Hongtao Ye, Yijun Li, Xia Gou, Juhong Zhang, Wei Yuan · 2026
Development of a photocaged CLIPTAC for spatiotemporal control of protein degradation
DOI 10.1016/j.bioorg.2026.110678 Jaeseok Lee, Junhyeong Yim, Solbi Kim, Soyoung Yoon, Junyoung Park, Sihyeong Yi, Sunbin Jung, Ala Jo, Hankum Park, Jongmin Park · 2026
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