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Pharmacological Research
Published by Elsevier.
ISSN 1043-6618 / 1096-1186
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Aims & scope
Pharmacological Research publishes peer-reviewed research. Manuscripts pass a technical check and a scope check by the handling editor before going to independent reviewers.
02
Recently published
Polyol pathway inhibition by epalrestat attenuates pathological bone loss through redox homeostasis and sorbitol-linked calcium signaling
DOI 10.1016/j.phrs.2026.109698 Chengjun Yao, Zimin Cai, Haixin Song, Qize Xue, Bohan Cai, Wenyao He, Xiangxi Kong, Tao Yang, Jiayan Jin, Jie Li, Binhui Chen, Fengdong Zhao, Jia Chen, Jian Chen, Junhui Liu · 2026
Redox imbalance and epigenetic reprogramming underlie polysubstance-induced neuronal dysfunction
DOI 10.1016/j.phrs.2026.109703 Karthick Chennakesavan, Haylee R. Hammond, Nakulan Kalaisejiane, Shyam Devan, Abhinav Karnati, Shainnel O. Eans, Ashai K. Williams, Jay P. McLaughlin, Thangavel Samikkannu · 2026
Orchestrating stress granule dynamics by SUMOylation: A new frontier in treating stress-induced age-related diseases
DOI 10.1016/j.phrs.2026.108464 Jiacheng Zhang, Hangqi Hu, Yutian Zhu, Xiyan Xin, Ruiwen Fan, Yang Ye, Dong Li · 2026
Paeoniflorigenone triggers TRIM28 phosphorylation-dependent ferroptosis and immune activation to suppress intrahepatic cholangiocarcinoma
DOI 10.1016/j.phrs.2026.109652 Kainan Lin, Yunkun Lu, Zhihao Lin, Jie Dou, Qianqian Wang, Yang Liu, Xing Jia, Yuanqiang Li, Xuefei Yu, Danqing Wang, Qinglin Li, Xiujun Cai, Renan Jin · 2026
Three-dimensional cell culture models in oncology: From tumour spheroids to integrated microphysiological systems
DOI 10.1016/j.phrs.2026.108465 Eva Martin, Flavien Bessaguet, Nicolas Clere · 2026
Gut microbiota modulates nonalcoholic fatty liver disease (NAFLD) progression via regulation of gluconeogenesis: mechanisms and translational research
DOI 10.1016/j.phrs.2026.108444 WeiZhou Wang, YunTao Tang, ZiQian Wan, ZhiQuan Zhang, ZhouHang Zheng, HuiLong Liu, QiPeng Shu, ShangZe Li · 2026
Targeting bone marrow mesenchymal stem cells with traditional Chinese medicine active ingredients: Restoring hematopoietic microenvironment homeostasis to prevent and treat myelosuppression
DOI 10.1016/j.phrs.2026.108460 Jingnan Yan, Yafeng Qi, Jiajun Guo, Xiaodan Jiang, Jingwei Li, Jiayi Wan, Qian Xv, Lumei Zhang, Yangyang Li, Liying Zhang, Zhiming Zhang · 2026
Leucine-derived isovaleric acid remodels the tumor microenvironment by degrading EIF3I
DOI 10.1016/j.phrs.2026.109666 Jiahui Xu, Ziming Wang, Chunli Wei, Jin Liao, Yongkai Liang, Tingting Zhao, Xuetong Ding, Jinling Li, Yuqing Niu, Yuwei Wang, Jumin Huang, Elaine Lai-Han Leung · 2026
DHA in Alzheimer’s disease: The translational gap between mechanistic complexity and clinical inconsistency
DOI 10.1016/j.phrs.2026.108479 Xinhua Li, Yue Jin, Xiaoyu Li, Minqi Chen, Chuanzhi Kang, Hongyuan Lu, Huiyuan Gao, Xiaowen Jiang · 2026
Nε-(Carboxymethyl)lysine induces mitochondrial stress, inflammatory activation, and fibrogenic remodelling in multicellular human liver organoids
DOI 10.1016/j.phrs.2026.109653 Jin Young Min, Min Ji Gu, Hye Min Kim, Donghwan Kim, Geul Bang, Sang-Yeop Lee, Hae Won Jung, Kwan Soo Hong, Dae Won Jun, Seung Min Lee, Sang Keun Ha, Eun Hee Han · 2026
Nifedipine-modulated gut microbiota attenuates hypertensive vascular injury through Bifidobacterium-associated inosine-Adora2b signaling
DOI 10.1016/j.phrs.2026.109684 Xiaoyu Ren, Xuefang Yan, Ping Tang, Jiajia Jin, Zihan Qin, Yun Zhang, Tongxue Zhang, Guixiang Yao, Xianlun Yin, Zhuo Zhao, Zhe Wang, Qunye Zhang · 2026
CAMKK1 couples STIM1-dependent Ca2+ signaling to mitochondrial metabolic adaptation during osteoclastogenesis
DOI 10.1016/j.phrs.2026.109671 Qian Ren, Yibo Ma, Yansheng Huang, Yuan Liu, Xuefang Zhang, Shuaijun Jia, Liang Yan, Sibo Wang · 2026
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