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Medicinal Chemistry Research
Published by Springer-Verlag.
ISSN 1054-2523 / 1554-8120
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Aims & scope
Medicinal Chemistry Research publishes peer-reviewed research. Manuscripts pass a technical check and a scope check by the handling editor before going to independent reviewers.
02
Recently published
Small-molecule ferroptosis inducers and sensitizers in anticancer drug discovery: medicinal chemistry, structure–activity relationships, and translational perspectives
DOI 10.1007/s00044-026-03632-4 Aashik Malik, Md Arif Naseer, Mayank Yadav, Zulphikar Ali, Jai Parkash Kadian · 2026
Azole chroman-4-one, tetralone and chromen-4-one derivatives: synthesis, Mycobacterium tuberculosis CYP121A1 enzyme inhibition and antimycobacterial activity
DOI 10.1007/s00044-026-03631-5 Jabril M. Abdali, Lama A. Alshabani, Alistair K. Brown, Amit Kumar, Sam Wilcocks, Ahmed Y. G. Alhejaili, Sanjida Y. Kalam, D. Fernando Estrada, Claire Simons · 2026
Structure-based discovery of acridone alkaloids as disruptors of the HEG1–KRIT1 protein–protein interaction in cerebral cavernous malformation signaling
DOI 10.1007/s00044-026-03627-1 Emadeldin M. Kamel, May Bin-Jumah, Haifa E. Alfassam, Raghad A Alotaibi, Ahmed A. Allam, Fahad M. Alshabrmi, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi · 2026
Coumarin scaffolds in breast cancer research: derivatives, hybrids, and therapeutic potential
DOI 10.1007/s00044-026-03629-z Shagufta, Irshad Ahmad, Isha Khan, Maimonah Al Zubaidi, Aayat Aladhamy · 2026
Bicyclononane-2,8-bis(trifluoromethyl)quinoline hybrids: synthesis, antiplasmodial and antitrypanosomal activity
DOI 10.1007/s00044-026-03628-0 Johanna Dolensky, Werner Seebacher, Eva-Maria Pferschy-Wenzig, Miriam Zehentner, Robert Saf, Pascal Mäser, Monica Cal, Robert Weis · 2026
Special issue of Medicinal Chemistry Research in honor of Dr. Kenneth A. Jacobson
DOI 10.1007/s00044-026-03630-6 Carola Gallo-Rodriguez, Juan Bautista Rodriguez, Pnina Fishman · 2026
From danger to resolution: targeting purinergic signaling in CNS diseases
DOI 10.1007/s00044-026-03583-w Camille Degryse, Kirti Gupta, Luc Buée, Thierry Burnouf, David Blum, Ming-Li Chou · 2026
Vepdegestrant: the first FDA-approved oral PROTAC and a milestone in targeted protein degradation
DOI 10.1007/s00044-026-03622-6 Jeffrey Yang, Longqin Hu · 2026
Baxdrostat (Baxfendy®), a first-in-class aldosterone synthase inhibitor approved for adults with uncontrolled hypertension
DOI 10.1007/s00044-026-03620-8 Ahmed R. Ali, Longqin Hu · 2026
Design and biological evaluation of sulfonamide–chalcone hybrids with in vitro tumor-selective cytotoxicity against oral squamous cell carcinoma: SAR, QSAR, and in silico ADME studies
DOI 10.1007/s00044-026-03624-4 Gulsen Ozli, Hiroshi Sakagami, M. Fatih Polat, Cavit Kazaz, Kota Kurosaki, Yoshihiro Uesawa, Kaito Inden, Halise Inci Gul · 2026
Glypican-3-targeted bioconjugates for hepatocellular carcinoma: design, engineering, and translational applications
DOI 10.1007/s00044-026-03625-3 Yi Liu, Jiaying Zhu, Haolei Yu, Chenyu Wang, Yue You, Zixuan Hong, Chenbo Zhang, Chenpengyu Zhang, Zhihao Zhang · 2026
Optimization of a bis-imine scaffold as a glyoxalase I inhibitor: synthesis, SAR, and docking studies
DOI 10.1007/s00044-026-03626-2 Buthina A. Al-Oudat, Farah B. Al-Omari, Suaad A. Audat, Nizar A. Al-Shar’i, Qosay A. Al-Balas · 2026
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