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Letters in Drug Design & Discovery
Published by Elsevier.
ISSN 1570-1808 / 1875-628X
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Aims & scope
Letters in Drug Design & Discovery publishes peer-reviewed research. Manuscripts pass a technical check and a scope check by the handling editor before going to independent reviewers.
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Recently published
Network pharmacology-based identification and molecular docking with dynamics simulation of phytochemicals from Centella asiatica, Panax ginseng, and Rosmarinus officinalis as potential multi-target therapeutics against Ischemic Stroke
DOI 10.1016/j.lddd.2026.100646 Sangavi Pandi, Arumugam Kamaladevi, Ibrahim Nabirathaslima, Pandiyan Muthuramalingam, Thimma Mohan Viswanathan, Sindhuja KV, Langeswaran Kulanthaivel · 2026
QSAR-guided design, DFT, molecular docking, and ADMET prediction of novel thiazolidinone-based indole derivatives as potent α-glucosidase inhibitors
DOI 10.1016/j.lddd.2026.100624 Augustine Onuche Sule, Mary Ikhaote Ohiole, Modupe Abimbola Olatunde, Kehinde Gabriel Obiyenwa, Elizabeth Funke Olarinoye, Nathaniel Oladoye Olatunji, Banjo Semire · 2026
Evolution of endocrine therapy for advanced prostate cancer: Breakthroughs and resistance mechanisms from traditional antiandrogens to novel AR pathway inhibitors
DOI 10.1016/j.lddd.2026.100637 Ziqiang Liu, Jianhua Xiao, Ziqiang Dong · 2026
Design of novel drug candidates inhibiting coxsackie virus B3 (CVB3) using computer-aided methods: QSAR modeling, molecular docking, molecular dynamics, biological efficacy, retrosynthesis and quantum chemical calculations
DOI 10.1016/j.lddd.2026.100611 Youness Moukhliss, Yassine Koubi, Naanaai Lhoucine, Marwa Alaqarbeh, Hamid Maghat, Abdelouahid Sbai, Tahar Lakhlifi, Mohammed Bouachrine · 2026
Exploring the potential mechanisms of chrysophanol in the treatment of nonalcoholic fatty liver disease based on network pharmacology and experimental validation
DOI 10.1016/j.lddd.2026.100589 Fan Yang, Hu Li, Caocao Chen, Juan Ma, Qinglong Li, Xiaoguo Wei · 2026
Clinical and CT imaging features for predicting acquired osimertinib resistance in EGFR-mutant lung cancer
DOI 10.1016/j.lddd.2026.100632 Wenchao Lu, Lei Xu, Dong Song, Haiyan Xu · 2026
Chronic low-grade inflammation in polyendocrine metabolic ovarian syndrome: Metabolic dysregulation and the emerging link with metabolic dysfunction associated steatotic liver disease
DOI 10.1016/j.lddd.2026.100606 K. Meghana, C. Anchana Devi, Senthamil Selvi Poongavanam, Dharmalingam Kirubakaran, Chitrarasu Manikandan · 2026
Majoon Sarakhs: A polyherbal Unani formulation with total phenolics, flavonoids, in vitro antioxidant activity, and in silico molecular modeling insights for drug discovery
DOI 10.1016/j.lddd.2026.100638 Huda Nafees, Sana Nafees, Imran Khan, Mohamed L. Ashour, Fadia S. Youssef · 2026
Machine learning-based computational prediction of sirtuin-NF-κB regulatory axis driving inflammatory cell death in Alzheimer’s disease
DOI 10.1016/j.lddd.2026.100612 Rohan Gupta, Rupak Nagraik, Neha Kumari, Reetesh Kumar, Niraj Kumar Jha · 2026
Network pharmacology and experimental studies to investigate the effects of glycyrrhizic acid on cell viability, apoptosis, inflammatory response, and ferroptosis in LPS-induced pancreatic cellular injury
DOI 10.1016/j.lddd.2026.100651 Wentao Liu, Ze Zhou, Yufeng Zha, Shichao Liu, Bin Zhou, Zhili Wei · 2026
Design, synthesis, computational evaluation, and in vitro cytotoxicity assessment of coumarin-3-carboxamide derivatives against HeLa cervical cancer cells
DOI 10.1016/j.lddd.2026.100629 Vasyl Matiychuk, Asha Thomas, Oksana Khropot, Iryna Drapak, Prachi Prasad, Sham Tambe, Mansi Chavan, Pranali Jadhav, Kiran Lokhande, Trupti Borhade, Akshita Maheshwari, Chandrashekar Raut · 2026
Sevoflurane alleviates myocardial fibrosis by targeting the YTHDF1/AXL/ferroptosis axis
DOI 10.1016/j.lddd.2026.100607 Qiong Song, Lu Li, Wei Zhang, Jiaying Liu, Xiaochen Yang, Yanqing Lv, Jianzhuang Gong, Lijun Wang, Nai Sun · 2026
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