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Acta Pharmacologica Sinica
Published by Springer Science and Business Media LLC.
ISSN 1671-4083 / 1745-7254
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Aims & scope
Acta Pharmacologica Sinica publishes peer-reviewed research. Manuscripts pass a technical check and a scope check by the handling editor before going to independent reviewers.
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Recently published
TNF signaling at the brain-heart interface: neurovascular injury and cardiovascular vulnerability in epilepsy
DOI 10.1038/s41401-026-01949-9 Ao Sha, Yang Wu, Hao-ran Peng, Bo Jin, Bin He, Zhen-kun Zhao, Fang He, Yu Cao, Lu Gan · 2026
Transcription factor EB as a novel target for dimethyl fumarate to restore endothelial function in diabetes
DOI 10.1038/s41401-026-01944-0 Lei He, Ri Min Tan, Leyi Wu, Qinghua Chen, Jinzhao Yang, Ziyu Han, Yang Zhang, Gang Fan, Yu Huang, Cheng-Lin Zhang · 2026
ASIC1a promotes liver fibrosis by inhibiting METTL3 SUMOylation
DOI 10.1038/s41401-026-01951-1 Zi-hao Li, Meng-xue Li, Yong-hu Song, Ruo-han Ren, Ting-ting Zhang, Wan-jing Huang, Asena Musonye Harry, Kiramat Ali Shah, Yu-yan Wang, Zi-jun Liu, Hao-yang Chen, Shis-hun Qian, Zhou Xu, Jing-rong Zhang, Lynn Jia Tay, Zi-wen Zhang, Jun Liu, Cheng-mu Hu, Fu-rong Yang, Hui Hou, Wu-yi Sun, Xiang-peng Hu, Hua Wang, Jia-jia Wang, Fan-rong Wu, Yan Huang · 2026
Aloperine induces methuosis in non-small cell lung cancer by targeting VPS34 lactylation and disrupting the Armus/Rab7 axis
DOI 10.1038/s41401-026-01960-0 Xiao-hu Ou-Yang, Wei-na Guo, Jun Zhang, Liang-qing-qing Yin, Jing-bo Wang, Xiao-yuan Qiu, Shu-xin Song, Xiao-shuang Hou, Lan Lin, Cong Zhou, Jun-jie Lu, Ya-ting Lu, Ya-xuan Qi, Qing-rui Nong, Hao Chen, Ruo-nan Yu, Shan-shan Luo, Li-juan Zhang, De-sheng Hu · 2026
Anticancer drug discovery: Embracing the next wave of innovation
DOI 10.1038/s41401-026-01964-w Min Huang, Mei-yu Geng, Jian Ding · 2026
Inhibition of histone deacetylase 3 alleviates lithocholic acid-induced intrahepatic cholestasis by enhancing expression of bile acid and lipid homeostasis-related genes
DOI 10.1038/s41401-026-01950-2 Jing-shu Li, Xiao-wen Jiang, Pei-bin Chen, Xuan Li, Xiao Yang, Shi-cheng Fan, Yue Gao, Jian-hong Fang, Feng Qiu, Hui-chang Bi · 2026
A novel shark VNAR antibody-based immunotoxin targeting ERα36 disrupts non-genomic estrogen signaling and tumor metabolic reprogramming in breast cancer
DOI 10.1038/s41401-026-01941-3 Xiao-zhi Xi, Lin-lin Zhu, Zhuo Xiang, Li Yin, Gui-lai Chen, Yan-qing Wang, Xiao-chun Liu, Yu-chao Gu, Qiang Wang · 2026
Context-dependent vascular effects of platycodin D: inhibition of neointima formation but aggravation of atherosclerosis with involvement of mTORC1 signaling
DOI 10.1038/s41401-026-01933-3 Bin-Jie Yan, Darrell Belke, Yong-Xiang Chen, Xi-Long Zheng · 2026
Restoration of cyclin A2 by glabridin reverses pathological cell cycle arrest and drives cardiac repair in HFpEF
DOI 10.1038/s41401-026-01952-0 Meng-yao Wang, Ru-ru Pan, Jie Zhou, Xiao Wen, Sha-sha Chen, Chang Yuan, Yan-lu Han, Lu Tang, Hao Wang, Wen-quan Hu, Han Xiao, Ya-jun Duan, Ze-qun Yin, Shuang Zhang · 2026
Systematic optimization and characterization of the MidTAC platform for targeted protein degradation
DOI 10.1038/s41401-026-01959-7 Yu-bing Han, Si-hong Zhong, Ming-zhi Wang, Zhen-qian Fu, Yu-tong Tu, Jia Li, Yu-bo Zhou · 2026
MMP14-mediated proteolytic cleavage of LAMC2 domain III fragment drives osimertinib resistance in EGFR-mutant non-small cell lung cancer
DOI 10.1038/s41401-026-01901-x Cong-hua Lu, Wan-da Bi, Zi-yuan Gao, Dai-juan Huang, Cai-yu Lin, Di Wu, Hao-yue Yu, Yong He, Li Li · 2026
Correction: Je-Chun-Jun induced apoptosis of human cervical carcinoma HeLa cells
DOI 10.1038/s41401-026-01920-8 Han-jung Chae, Kyung-mi Park, Geun-youn Lee, Gi-seup Jeong, Hyung-rae Park, Hyung-min Kim, Soo-wan Chae, Shim-keun Yoo, Hyung-ryong Kim · 2026
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