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Molecular Systems Biology
Published by Springer Science and Business Media LLC.
ISSN 1744-4292 / 1744-4292
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Aims & scope
Molecular Systems Biology publishes peer-reviewed research. Manuscripts pass a technical check and a scope check by the handling editor before going to independent reviewers.
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Recently published
Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition
DOI 10.1038/s44320-026-00246-1 Clayton W Kosonocky, Alex M Abel, Aaron L Feller, Amanda E Cifuentes Rieffer, Phillip R Woolley, Jakub Lála, Daryl R Barth, Tynan Gardner, Daniel Acosta, Stefano Angioletti-Uberti, Vinayak Annapure, Neil Anthony, Rana A Barghout, Max Beining, Parth Bibekar, Dionessa Biton, Patrick Bryant, Anton Bushuiev, Cianna Calia, Ava Chan, Jie Chen, Akshay Chenna, Nicole Chiang, Vivian Chu, Joseph Clark, Alia Clark-ElSayed, Elliot Cole, Qian Cong, Shreyasi Das, Tanner Dean, Tyler Derr, Alejandro Diaz, Jesse Durham, Moritz Ertelt, Antonio Fonseca, Ora Furman, Tynan Gardner, Jokent Gaza, Nathaniel Greenwood, Rui Guo, Abel Gurung, Vivian Haas, Seyed Alireza Hashemi, Dieter Hoffmann, Sofiia Hoian, Corey Howe, Calvin XiaoYang Hu, Jinling Huang, Nader Ibrahim, Satoshi Ishida, Ansar Ahmad Javed, Aswini Javvadi, Roman Jerala, Daksh Joshi, Even Kiely, Haelyn Kim, Diego Kleiman, Sarah Knapp, Huan Koh, Petr Kouba, Yong Youn Kwon, Duško Lainšček, Jakub Lála, Hakyung Lee, Qiuzhen Li, Max Lingner, Yuxuan Liu, Yunchao Liu, Qianchen Liu, Ajasja Ljubetič, Marko Ludaic, Karl Lundquist, Ashish Makani, Javier Marchena-Hurtado, Freddie Martin, Jens Meiler, Fernando Meireles, David Miller, Nuria Mitjavila, Tjaša Mlakar, Rajarshi Mondal, Saeideh Moradvandi, Rocco Moretti, Sai Jaideep Reddy Mure, Pragati Naikare, Fatemeh Nasiri, Kaveh Nasrollahi, Yisel Martinez Noa, Joseph Openy, Aoi Otani, Vikrant Parmar, Jimin Pei, Alberto Perez, Rajat Punia, Francisco Requena, Dominic Rieger, Aparna Sahu, Elias Sanchez, Rohit Satija, Tadej Satler, Tom Schlegel, Yang Shen, Diwakar Shukla, Rangana De Silva, Benedikt Singer, Arjun Singh, Amardeep Singh, Bhumika Singh, Jinwoong Song, Harish Srinivasan, Hannah Stewart, Zhaoqian Su, Julia Varga, Xin Wang, Dion Whitehead, Matthew Williams, Max Witwer, Rujie Yin, Song Yin, Rongqing Yuan, Nikola Zadorozhny, Dishant Parag Zaveri, Genhui Zheng, Yizhen Zheng, Jian Zhou, Shaowen Zhu, Lin Zhu, Stephen C Ekker, Andrew D Ellington, Wesley A Wierson, Edward M Marcotte · 2026
Crowdsourcing functional cell therapy binders from generative artificial intelligence
DOI 10.1038/s44320-026-00249-y Abdul Vehab Dozic, Caleb A Lareau · 2026
Trade-off between flux efficiency and metabolic control shapes enzyme allocation
DOI 10.1038/s44320-026-00250-5 Kai Sun, Weiyan Zheng, Wenchao Fan, Chuyun Ding, Dan Huang, Ziwei Dai · 2026
Engineering a compact CgCas12n platform for efficient genome and base editing in mammalian cells
DOI 10.1038/s44320-026-00248-z Bowen Hou, Xinyi Liu, Jiawen Fan, Wanjie Wang, Chuanzhao Jin, Guanglei Li, Yu Zhang, Wenxia Yu, Lei Huang, Xinyun Li, Xingxu Huang, Kui Li · 2026
An integrated spatially defined roadmap of normal and cancer-associated colon fibroblasts
DOI 10.1038/s44320-026-00247-0 Emma W Viitala, Ella Salminen, Mitro Miihkinen, Toni T Lemmetyinen, Myriam Sévigny, Kiisla K Porvari, Tanisha Malpani, Niki Chalkidi, Athanasia Stavropoulou, Pekka J Päivinen, Tuomas Kaprio, Jaana Hagström, Caj Haglund, Tomi P Mäkelä, Pekka Katajisto, Tero Aittokallio, Vasiliki Koliaraki, Saara Ollila · 2026
Cell cycle-dependent protein dynamics in budding yeast resolved by deconvolution of bulk proteomics
DOI 10.1038/s44320-026-00241-6 Andre Zylstra, Mattia Rovetta, Silke R Vedelaar, Christian Bleischwitz, Julius A Fülleborn, Yulan van Oppen, Hugo P Markus, Kerlen T Korbeld, Enrico Calzati, Andreas Milias-Argeitis, Katarzyna Buczak, Alexander Schmidt, Matthias Heinemann · 2026
Decoding spatiotemporal fibrotic and cellular immunosuppression of therapeutic T cells in live pancreatic ductal adenocarcinoma
DOI 10.1038/s44320-026-00243-4 Guhan Qian, Hongrong Zhang, Ingunn M Stromnes, Kevin W Eliceiri, Paolo P Provenzano · 2026
Tracking cell fate through morphodynamics
DOI 10.1038/s44320-026-00244-3 Julia Dorr, Brian J Mitchell · 2026
Two essential criteria for transcription factor footprint discovery using V-plot
DOI 10.1038/s44320-026-00242-5 Qifan Zhang, Chenhuan Xu · 2026
Joint-RPCA: domain-aware multi-omics integration for systems microbiology
DOI 10.1038/s44320-026-00236-3 Bianca Cordazzo Vargas, Cameron Martino, Amanda Hazel Dilmore, Jessica L Metcalf, Zachary M Burcham, Leo Lahti, Aituar Bektanov, Tuomas Borman, Veikko Salomaa, Teemu Niiranen, Aki S Havulinna, Rachel Gregor, Stav Eyal, Michael M Meijler, Itzhak Mizrahi, Se Jin Song, Andrew Bartko, Pieter C Dorrestein, James T Morton, Daniel McDonald, Rob Knight, Liat Shenhav · 2026
Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays
DOI 10.1038/s44320-026-00240-7 Max Trauernicht, Vinícius H Franceschini-Santos, Hatice Yücel, Teodora Filipovska, Bas van Steensel · 2026
Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz
DOI 10.1038/s44320-026-00231-8 Christina Schmidt, Jannik Franken, Denes Turei, Dimitrios Prymidis, Macabe Daley, Christian Frezza, Julio Saez-Rodriguez · 2026
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